名词
中文翻译：重大挫折
同义词：
['major setback', 'major disappointment', 'significant setback']
例句：
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1. Hiscareer took a major setback after he was fired from his job.
他的职业生涯在被解雇后遭遇了重大挫折。
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2.She faced a major setback when her business failed to gain traction.
她的业务未能获得成功，遭遇了重大挫折。
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3.The team's performance fell short of expectations, resulting in a major setback.
团队的表现未达预期，结果遭遇了重大挫折。