角化过度

例句：

1. 1. The patient's skin was severely affected by the disease, with excessive keratinization.
   患者的皮肤严重受病影响，出现了过度角化。
2. 2. During the winter, the skin of the palms and soles becomes thickened due to keratinization.
   冬天时，手掌和脚底的皮肤会变得厚，这是因为角化过度。
3. 3. The doctor advised the patient to avoid prolonged exposure to the sun, as it can cause excessive keratinization.
   医生建议患者避免长时间暴露在阳光下，因为这样可能会导致过度角化。