名词
中文翻译：实质性问题
同义词：
['major issue', 'critical issue']
例句：
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1.The company is facing a substantial issue with its supply chain management.
该公司正面临供应链管理的重大挑战。
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2. This is a substantial issue that needs to be addressed urgently.
这是一个需要紧急解决的重大问题。
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3. The government has identified several substantial issues that need to be addressed in the next budget cycle.
政府已识别出几个需要在下一个预算周期解决的问题。